Plain, Discreet
Packaging
Tracked 24*7
Delivery
Spedra (avanafil)
- Available in 50mg, 100mg, and 200mg strengths
- One of the fastest-acting ED treatments available
- Taken on demand, 15–30 minutes before sexual activity
- UK Pharmacy
- GPhC Registered
- Discreet Delivery
Overview
Spedra is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. Its active ingredient is avanafil, which belongs to a group of medicines known as PDE5 inhibitors — the same family as sildenafil (Viagra) and tadalafil (Cialis).
Spedra is one of the fastest-acting ED treatments currently available. When taken on an empty stomach, it can begin working in as little as 15 minutes.
It is available in three strengths — 50mg, 100mg, and 200mg — allowing your prescriber to recommend the dose best suited to your needs.
Spedra is a prescription-only medicine (POM). It can only be supplied after an online clinical assessment has been reviewed and approved by a prescriber.
How Spedra Works
Like other PDE5 inhibitors, Spedra:
- Blocks the enzyme phosphodiesterase type 5 (PDE5)
- Supports the natural process of arousal by improving blood flow
- Requires sexual stimulation to be effective — it will not cause an erection on its own
LEARN MORE ABOUT THIS TREATMENT
How Spedra Works
Spedra works by relaxing the blood vessels in the penis, allowing increased blood flow when you are sexually aroused. This helps you achieve and maintain an erection firm enough for sexual activity.
Like other PDE5 inhibitors, Spedra:
- Blocks the enzyme phosphodiesterase type 5 (PDE5)
- Supports the natural process of arousal by improving blood flow
- Requires sexual stimulation to be effective — it will not cause an erection on its own
Spedra does not increase sexual desire. Without arousal and normal foreplay, the effects of the tablet will simply wear off over a few hours.
How to Take Spedra
Strengths available:
50mg, 100mg, 200mg tablets.
Dosage guidance
- The usual starting dose is 100mg, taken approximately 15–30 minutes before sexual activity.
- This may be adjusted to 50mg (if the starting dose is highly effective) or 200mg (if the starting dose provides unsatisfactory results).
- Swallow the tablet whole with water.
- Do not take more than one tablet in any 24-hour period.
- Do not take Spedra within 24 hours of another ED medication.
- Effects may begin within 15–30 minutes for the 100mg and 200mg strengths, or around 30 minutes for the 50mg strength.
- Spedra typically remains active for around 4–6 hours.
- Sexual stimulation is required for the treatment to work.
Food and alcohol
- Spedra can be taken with or without food, but it works fastest on an empty stomach.
- If taken after a meal, absorption may be delayed by up to 90 minutes or more.
- Alcohol can reduce the ability to achieve an erection and may increase the risk of side effects such as dizziness and low blood pressure.
Choosing your strength
Safety and Side Effects
Spedra is generally well tolerated, but like all medicines, side effects can occur.
Common side effects (may affect up to 1 in 10 men)
- Headache
- Flushing (face or skin going red)
- Nasal or sinus congestion
- Back pain
- Dizziness
- Nausea or indigestion
Seek urgent medical attention if you experience
- An erection lasting longer than 4 hours (priapism) — this requires immediate treatment to prevent lasting damage
- Sudden decrease or loss of vision in one or both eyes
- Sudden decrease or loss of hearing, sometimes with ringing in the ears or dizziness
- Blurred vision
Who should not take Spedra
- Take nitrates (used for angina or heart conditions) — this combination can cause a dangerous drop in blood pressure
- Use recreational nitrate drugs (sometimes known as "poppers")
- Have recently had a stroke or heart attack
- Have severe heart or liver problems
- Have low blood pressure or uncontrolled high blood pressure
- Have been advised to avoid sexual activity for medical reasons
Patient Information Leaflet
For full usage and safety information, please read the official patient information leaflet provided with the product.
Spedra 50mg PIL
Spedra 100mg PIL
Spedra 200mg PIL
How Spedra Compares
| Feature | Spedra (avanafil) | Sildenafil | Tadalafil |
| Time to take effect | 15–30 minutes | 30–60 minutes | 30–60 minutes |
| Duration | 4–6 hours | 4–6 hours | Up to 36 hours |
| Food impact | Delayed if taken with food | Delayed if taken with food | Minimal effect |
| Typical use | On demand | On demand | On demand or daily |
Author Information
All of our medication and condition content is written by UK qualified pharmacists and doctors.
Authored by
Amit Raj
Superintendent Pharmacist
Reviewed by
XXXXXXXXXX
Medical Advisor / Pharmacist or Doctor
GPhC Number: 225377
Review Date:
XX March 2026
Next Review:
XX March 2027
Published on:
XX March 2026
Last Update:
XX March 2026
FREQUENTLY ASKED QUESTIONS
Trust and Regulation
- UK Clinicians
- Regulated Pharmacy
- Discreet Delivery
Overview
Plain, Discreet
Packaging
Tracked 24*7
Delivery
Spedra (avanafil)
- Available in 50mg, 100mg, and 200mg strengths
- One of the fastest-acting ED treatments available
- Taken on demand, 15–30 minutes before sexual activity
- UK Pharmacy
- GPhC Registered
- Discreet Delivery
Overview
Spedra is a prescription-only medicine used to treat erectile dysfunction (ED) in adult men. Its active ingredient is avanafil, which belongs to a group of medicines known as PDE5 inhibitors — the same family as sildenafil (Viagra) and tadalafil (Cialis).
Spedra is one of the fastest-acting ED treatments currently available. When taken on an empty stomach, it can begin working in as little as 15 minutes.
It is available in three strengths — 50mg, 100mg, and 200mg — allowing your prescriber to recommend the dose best suited to your needs.
Spedra is a prescription-only medicine (POM). It can only be supplied after an online clinical assessment has been reviewed and approved by a prescriber.
How Spedra Works
Like other PDE5 inhibitors, Spedra:
- Blocks the enzyme phosphodiesterase type 5 (PDE5)
- Supports the natural process of arousal by improving blood flow
- Requires sexual stimulation to be effective — it will not cause an erection on its own
LEARN MORE ABOUT THIS TREATMENT
How Spedra Works
Spedra works by relaxing the blood vessels in the penis, allowing increased blood flow when you are sexually aroused. This helps you achieve and maintain an erection firm enough for sexual activity.
Like other PDE5 inhibitors, Spedra:
- Blocks the enzyme phosphodiesterase type 5 (PDE5)
- Supports the natural process of arousal by improving blood flow
- Requires sexual stimulation to be effective — it will not cause an erection on its own
Spedra does not increase sexual desire. Without arousal and normal foreplay, the effects of the tablet will simply wear off over a few hours.
How to Take Spedra
Strengths available:
50mg, 100mg, 200mg tablets.
Dosage guidance
- The usual starting dose is 100mg, taken approximately 15–30 minutes before sexual activity.
- This may be adjusted to 50mg (if the starting dose is highly effective) or 200mg (if the starting dose provides unsatisfactory results).
- Swallow the tablet whole with water.
- Do not take more than one tablet in any 24-hour period.
- Do not take Spedra within 24 hours of another ED medication.
- Effects may begin within 15–30 minutes for the 100mg and 200mg strengths, or around 30 minutes for the 50mg strength.
- Spedra typically remains active for around 4–6 hours.
- Sexual stimulation is required for the treatment to work.
Food and alcohol
- Spedra can be taken with or without food, but it works fastest on an empty stomach.
- If taken after a meal, absorption may be delayed by up to 90 minutes or more.
- Alcohol can reduce the ability to achieve an erection and may increase the risk of side effects such as dizziness and low blood pressure.
Choosing your strength
Safety and Side Effects
Spedra is generally well tolerated, but like all medicines, side effects can occur.
Common side effects (may affect up to 1 in 10 men)
- Headache
- Flushing (face or skin going red)
- Nasal or sinus congestion
- Back pain
- Dizziness
- Nausea or indigestion
Seek urgent medical attention if you experience
- An erection lasting longer than 4 hours (priapism) — this requires immediate treatment to prevent lasting damage
- Sudden decrease or loss of vision in one or both eyes
- Sudden decrease or loss of hearing, sometimes with ringing in the ears or dizziness
- Blurred vision
Who should not take Spedra
- Take nitrates (used for angina or heart conditions) — this combination can cause a dangerous drop in blood pressure
- Use recreational nitrate drugs (sometimes known as "poppers")
- Have recently had a stroke or heart attack
- Have severe heart or liver problems
- Have low blood pressure or uncontrolled high blood pressure
- Have been advised to avoid sexual activity for medical reasons
Patient Information Leaflet
For full usage and safety information, please read the official patient information leaflet provided with the product.
Spedra 50mg PIL
Spedra 100mg PIL
Spedra 200mg PIL
How Spedra Compares
| Feature | Spedra (avanafil) | Sildenafil | Tadalafil |
| Time to take effect | 15–30 minutes | 30–60 minutes | 30–60 minutes |
| Duration | 4–6 hours | 4–6 hours | Up to 36 hours |
| Food impact | Delayed if taken with food | Delayed if taken with food | Minimal effect |
| Typical use | On demand | On demand | On demand or daily |
Author Information
All of our medication and condition content is written by UK qualified pharmacists and doctors.
Authored by
Amit Raj
Superintendent Pharmacist
Reviewed by
XXXXXXXXXX
Medical Advisor / Pharmacist or Doctor
GPhC Number: 225377
Review Date:
XX March 2026
Next Review:
XX March 2027
Published on:
XX March 2026
Last Update:
XX March 2026
FREQUENTLY ASKED QUESTIONS
Trust and Regulation
- UK Clinicians
- Regulated Pharmacy
- Discreet Delivery